Model-based evaluation of transmissibility and reinfection for the P.1 variant of the SARS-CoV-2

  title={Model-based evaluation of transmissibility and reinfection for the P.1 variant of the SARS-CoV-2},
  author={Renato Mendes Coutinho and Fl{\'a}via Maria Darcie Marquitti and Leonardo Souto Ferreira and M. E. Borges and R P Silva and O. Canton and Tatiana Pineda Portella and Silas P. Lyra and Caroline Franco and A. da Silva and Roberto Andr{\'e} Kraenkel and Maria Am{\'e}lia Veras and Paulo In{\'a}cio Prado},
The variant of concern (VOC) P.1 emerged in the Amazonas state (Brazil) and was sequenced for the 1st time on 6-Jan-2021 by the Japanese National Institute of Infectious Diseases. It contains a constellation of mutations, ten of them in the spike protein. Consequences of these mutations at the populational level have been poorly studied so far. From December-2020 to February-2021, Manaus was devastated by four times more cases compared to the previous peak (April-2020). Here, data from the… 

Modelling of Waning of Immunity and Reinfection Induced Antibody Boosting of SARS-CoV-2 in Manaus, Brazil

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The increase in the risk of severity and fatality rate of covid-19 in southern Brazil after the emergence of the Variant of Concern (VOC) SARS-CoV-2 P.1 was greater among young adults without pre-existing risk conditions

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This review attempts to aid in understanding the currently most important strains and what primary changes they entail in connection to more specific mutations, and how they each affect infectivity, antigen resistance, and other properties.

Detection of SARS-CoV-2 lineage P.1 in patients from a region with exponentially increasing hospitalization rates in February 2021, Rio Grande do Sul, Southern Brazil

Whole-genome sequencing revealed that the previously undetected P.1 lineage accounted for 88.9% of specimens collected from patients at a referral COVID-19 hospital, which raises concerns regarding a possible association between lineage P. 1 and rapid growth in cases and hospitalizations.

COVID-19 in northeast Brazil: first year of the pandemic and uncertainties to come

The Brazilian NE and the country are in increasingly complicated health, social and economic situations, and it is necessary to speed up vaccinations and maintain non-pharmacological measures: face masks, social distancing measures and hygiene care, in addition to policies to protect workers who have lost their incomes and to subsidize small business owners.

The next phase of SARS-CoV-2 surveillance: real-time molecular epidemiology.

A systematic approach is needed to link global genomic surveillance and timely assessment of the phenotypic characteristics of novel variants, which will support the development and updating of diagnostics, vaccines, therapeutics and nonpharmaceutical interventions.

The COVID-19 Vaccination Strategy in Brazil—A Case Study

The Brazilian COVID-19 vaccination campaign and the drivers and barriers to its implementation are described; and further investigations needed to have a conclusive overview over the constantly evolving situation are evaluated.



COVID-19 epidemic in the Brazilian state of Amazonas was driven by long-term persistence of endemic SARS-CoV-2 lineages and the recent emergence of the new Variant of Concern P.1

Findings support that successive lineage replacements in Amazonas were driven by a complex combination of variable levels of social distancing measures and the emergence of a more transmissible VOC P.1.1 virus.

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A second crisis has stunned the city of Manaus, and raises questions around a new variant and the likelihood of natural herd immunity.

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Genomics and epidemiology of a novel SARS-CoV-2 lineage in Manaus, Brazil

A novel SARS-CoV-2 variant of concern, lineage P.1, that acquired 17 mutations, including a trio in the spike protein associated with increased binding to the human ACE2 receptor, is identified in Manaus, Brazil.

Phylogenetic relationship of SARS-CoV-2 sequences from Amazonas with emerging Brazilian variants harboring mutations E484K and N501Y in the Spike protein

  • Virological
  • 2021

Brief report: New Variant Strain of SARS-CoV-2 Identified in Travelers from Brazil. Coronavirus disease 4

    Plots from Rede Genômica Fiocruz website