Model-based evaluation of drug-induced QTc prolongation for compounds in early development.

  title={Model-based evaluation of drug-induced QTc prolongation for compounds in early development.},
  author={Vincent F. S. Dubois and Huixin Yu and Meindert Danhof and Oscar Della Pasqua},
  journal={British journal of clinical pharmacology},
  volume={79 1},
AIMS Significant differences between dogs and humans have been observed in the concentration-QTc effect relationship of compounds with known pro-arrhythmic properties. These findings suggest that interspecies differences must be considered when evaluating drug effects. The aim of this study was to evaluate the performance of a model-based approach to assess the risk of QTc prolongation for three investigational compounds (NCE01, NCE02 and NCE03). METHODS Pharmacokinetic and pharmacodynamic… CONTINUE READING
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