Model-based deconvolution of genome-wide DNA binding

  title={Model-based deconvolution of genome-wide DNA binding},
  author={David J. Reiss and Marc T. Facciotti and Nitin S. Baliga},
  volume={24 3},
MOTIVATION Chromatin immunoprecipitation followed by hybridization to a genomic tiling microarray (ChIP-chip) is a routinely used protocol for localizing the genomic targets of DNA-binding proteins. The resolution to which binding sites in this assay can be identified is commonly considered to be limited by two factors: (1) the resolution at which the genomic targets are tiled in the microarray and (2) the large and variable lengths of the immunoprecipitated DNA fragments. RESULTS We have… CONTINUE READING