Model Study of the Pressure Build-Up during Subcutaneous Injection

Abstract

In this study we estimate the subcutaneous tissue counter pressure during drug infusion from a series of injections of insulin in type 2 diabetic patients using a non-invasive method. We construct a model for the pressure evolution in subcutaneous tissue based on mass continuity and the flow laws of a porous medium. For equivalent injection forces we… (More)
DOI: 10.1371/journal.pone.0104054

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