Model Study of the Pressure Build-Up during Subcutaneous Injection

Abstract

In this study we estimate the subcutaneous tissue counter pressure during drug infusion from a series of injections of insulin in type 2 diabetic patients using a non-invasive method. We construct a model for the pressure evolution in subcutaneous tissue based on mass continuity and the flow laws of a porous medium. For equivalent injection forces we measure the change in the infusion rate between injections in air at atmospheric pressure and in tissue. From a best fit with our model, we then determine the flow permeability as well as the bulk modulus of the tissue, estimated to be of the order 10-11-10-10 m2 and 105 Pa, respectively. The permeability is in good agreement with reported values for adipose porcine tissue. We suggest our model as a general way to estimate the pressure build-up in tissue during subcutaneous injection.

DOI: 10.1371/journal.pone.0104054

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@inproceedings{Thomsen2014ModelSO, title={Model Study of the Pressure Build-Up during Subcutaneous Injection}, author={Maria F Thomsen and Anier Hernandez-Garcia and Joachim Mathiesen and Mette N\ohr Poulsen and Dan N\ortoft S\orensen and Lise Tarnow and Robert Feidenhans'l}, booktitle={PloS one}, year={2014} }