Model Structure of Human APOBEC3G

  title={Model Structure of Human APOBEC3G},
  author={Kun-Lin Zhang and Bastien Mangeat and Mill{\'a}n Ortiz and Vincent Zoete and Didier Trono and Amalio Telenti and Olivier Michielin},
  journal={PLoS ONE},
  pages={1067 - 1076}
BACKGROUND APOBEC3G (apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G) has antiretroviral activity associated with the hypermutation of viral DNA through cytosine deamination. APOBEC3G has two cytosine deaminase (CDA) domains; the catalytically inactive amino-terminal domain of APOBEC3G (N-CDA) carries the Vif interaction domain. There is no 3-D structure of APOBEC3G solved by X-ray or nuclear magnetic resonance. METHODOLOGY/PRINCIPAL FINDINGS We predicted the structure of… CONTINUE READING


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