Model-Based Linkage Analysis of a Quantitative Trait.

  title={Model-Based Linkage Analysis of a Quantitative Trait.},
  author={Yeunjoo E. Song and Sunah Song and Audrey H. Schnell},
  journal={Methods in molecular biology},
Linkage Analysis is a family-based method of analysis to examine whether any typed genetic markers cosegregate with a given trait, in this case a quantitative trait. If linkage exists, this is taken as evidence in support of a genetic basis for the trait. Historically, linkage analysis was performed using a binary disease trait, but has been extended to include quantitative disease measures. Quantitative traits are desirable as they provide more information than binary traits. Linkage analysis… CONTINUE READING

Topics from this paper.