Model‐based analysis of trial data: microfilaria and worm‐productivity loss after diethylcarbamazine–albendazole or ivermectin–albendazole combination therapy against Wuchereria bancrofti

@article{deKraker2006ModelbasedAO,
  title={Model‐based analysis of trial data: microfilaria and worm‐productivity loss after diethylcarbamazine–albendazole or ivermectin–albendazole combination therapy against Wuchereria bancrofti},
  author={Marlieke E. A. de Kraker and Wilma A. Stolk and Gerrit J. Van Oortmarssen and J. Dik F. Habbema},
  journal={Tropical Medicine \& International Health},
  year={2006},
  volume={11}
}
Objectives  To determine the efficacies of combinations of ivermectin or diethylcarbamazine and albendazole, which are recommended for use in mass treatment programmes against lymphatic filariasis. 
Challenges in drug discovery for novel antifilarials
TLDR
The existing screening tools available for antifilarial drug discovery and efforts towards optimising their use through the Helminth Drug Initiative are discussed. Expand
Current Evidence on the Use of Antifilarial Agents in the Management of Bancroftian Filariasis
TLDR
This narrative review summarizes the current evidence for drug management of bancroftian filariasis and shows that doxycycline therapy against Wolbachia, an endosymbiotic bacterium of the parasite, is capable of reducing microfilaria rates and adult worm activity. Expand
Mathematical modelling of lymphatic filariasis elimination programmes in India: required duration of mass drug administration and post-treatment level of infection indicators
TLDR
To achieve elimination in high transmission settings, MDA must be continued longer and infection levels must be reduced to lower levels than in low-endemic communities, according to the required duration of annual MDA. Expand
Effect of single-dose ivermectin on Onchocerca volvulus: a systematic review and meta-analysis.
TLDR
A systematic review of individual and population-based ivermectin trials to investigate the temporal dynamics of the drug's microfilaricidal and embryostatic efficacy after administration of a single, standard dose (150 microg/kg). Expand
Improvement in the efficacy of existing combination of antifilarials by inclusion of tetracycline in rodent model of brugian filariasis
TLDR
The present findings strongly suggest the limited clinical trial of tetracycline in combination with the standard filaricides, although it alone did not demonstrate any significant embryostatic efficacy when administered for five consecutive days. Expand
Efficacy and safety of drug combinations in the treatment of schistosomiasis, soil-transmitted helminthiasis, lymphatic filariasis and onchocerciasis.
  • A. Olsen
  • Medicine
  • Transactions of the Royal Society of Tropical Medicine and Hygiene
  • 2007
TLDR
Results with ALB added to single-drug therapy with IVM or DEC against lymphatic filariasis were inconclusive, but DEC and IVM in combination appeared to be superior to DEC or IVM alone. Expand
Advances and challenges in predicting the impact of lymphatic filariasis elimination programmes by mathematical modelling
TLDR
The two main challenges for future modelling work are quantification and validation of the models for other regions, for investigation of elimination prospects in situations with other vector-parasite combinations and endemicity levels than in Pondicherry. Expand
Modelling the health impact and cost-effectiveness of lymphatic filariasis eradication under varying levels of mass drug administration scale-up and geographic coverage
TLDR
This analysis provides economic support for increasing the intensity of MDA programmes by assessing the health benefits and the incremental cost-effectiveness ratios (ICERs) associated with LF eradication, and projected the potential savings due to decreased morbidity management needs, and estimated potential household productivity gains as a result of reduced LF-related morbidity. Expand
Sequential Modelling of the Effects of Mass Drug Treatments on Anopheline-Mediated Lymphatic Filariasis Infection in Papua New Guinea
TLDR
Temporal invariance of biological parameters in the face of intervention perturbations indicates a robust adaptation of LF transmission to local ecological conditions and implies that understanding the mechanisms that underlie locally adapted transmission dynamics will be integral to identifying points of system fragility, and thus countermeasures to reliably facilitate LF extinction both locally and globally. Expand
The Impact of a Filariasis Control Program on Lihir Island, Papua New Guinea
TLDR
The results provide the data that supports the recommendation that high endemic areas may require longer duration MDA programs, or alternative control strategies. Expand
...
1
2
3
...

References

SHOWING 1-10 OF 32 REFERENCES
The role of albendazole in programmes to eliminate lymphatic filariasis.
TLDR
The potential of albendazole as a macrofilaricide for treating individual patients with lymphatic filarial infections is emphasized as one of a number of important research questions that remain to be explored. Expand
Efficacy of ivermectin in the treatment of Wuchereria bancrofti infection: a model-based analysis of trial results.
TLDR
It is found that irrespective of dosage, ivermectin eliminates 100% of the blood mf from a patient, and at a dosage level of 400 micrograms/kg a single treatment irreversibly reduces the mf production of the adult parasites by at least 65%. Expand
Ivermectin for the chemotherapy of bancroftian filariasis: a meta‐analysis of the effect of single treatment
TLDR
It is suggested that ivermectin given at a single annual dose of 200 μg/kg body weight or higher, whether or not in combination with DEC, has great potential for therapeutic strategies to control bancroftian filariasis. Expand
Ultrasonographic assessment of the adulticidal efficacy of repeat high‐dose ivermectin in bancroftian filariasis
TLDR
Even when given in total doses of 4.8 mg/kg, ivermectin appears to have no observable activity against adult W. bancrofti, although its ability to suppress microfilaraemia makes it potentially useful for the control of lymphatic filariasis. Expand
Treatment strategies underpinning the global programme to eliminate lymphatic filariasis
TLDR
The evidence for the efficacy and safety of these two-drug regimens underpinning the global strategy for elimination of LF are reviewed, and recommendations for future developments in chemotherapy for LF are made, focusing on unresolved issues. Expand
Efficacy of diethylcarbamazine in eradicating infection with lymphatic-dwelling filariae in humans.
  • E. Ottesen
  • Medicine
  • Reviews of infectious diseases
  • 1985
TLDR
A review of available evidence suggests that relatively high total dosages of DEC generally give better long-term therapeutic results than lower dosages, and spaced doses of DEC are more effective than the same total dosage given in consecutive daily doses. Expand
Randomised placebo-controlled comparison of ivermectin and albendazole alone and in combination for Wuchereria bancrofti microfilaraemia in Haitian children
TLDR
Assessment of the potential for school-based control of lymphatic filariasis by investigating the efficacy and tolerability or combined ivermectin and albendazole in Haitian schoolchildren found combined treatment with iverfilaraemic children with W bancrofti microfilarAemia was more effective than treatment withivermECTin only, with no measurable increase in severity of adverse reactions. Expand
Efficacy of single dose combinations of albendazole, ivermectin and diethylcarbamazine for the treatment of bancroftian filariasis.
TLDR
Alb/iver is a safe and effective single dose regimen for suppression of microfilaraemia in bancroftian filariasis that could be considered for control programmes and potential relative safety in areas of Africa where DEC cannot be used for Filariasis control. Expand
Treatment of co-infection with bancroftian filariasis and onchocerciasis: a safety and efficacy study of albendazole with ivermectin compared to treatment of single infection with bancroftian filariasis
TLDR
Treatment with ivermectin plus albendazole is a safe and tolerable treatment for co-infection of bancroftian filariasis and onchocerciasis and there was no significant difference in the reduction of microfilaraemia following treatment with albENDazole and iverMectin in groups with single or co- Infection. Expand
The dynamics of Wuchereria bancrofti infection: a model-based analysis of longitudinal data from Pondicherry, India
TLDR
A model-based analysis of longitudinal data describing the impact of integrated vector management on the intensity of Wuchereria bancrofti infection in Pondicherry, India gained insight into the dynamics of infection, with emphasis on the possible role of immunity, and a model that can be used to predict the effects of control was developed. Expand
...
1
2
3
4
...