Mode of regulation of the extracellular signal-regulated kinases in the pancreatic beta-cell line MIN6 and their implication in the regulation of insulin gene transcription.

@article{Benes1999ModeOR,
  title={Mode of regulation of the extracellular signal-regulated kinases in the pancreatic beta-cell line MIN6 and their implication in the regulation of insulin gene transcription.},
  author={Cyril Benes and Vincent Poitout and Julien C. Marie and Jorge Mart{\'i}n-P{\'e}rez and Marie Paule Roisin and R{\'e}mi Fagard},
  journal={The Biochemical journal},
  year={1999},
  volume={340 ( Pt 1)},
  pages={219-25}
}
Physiological concentrations of glucose that lead to Ca2+ entry and insulin secretion activate extracellular signal-regulated protein kinases (ERK1 and ERK2) in the MIN6 pancreatic beta-cell line. Here we show that this activation is inhibited by the down-regulation of protein kinase C (PKC) and by genistein, an inhibitor of protein tyrosine kinases. In contrast with results obtained in other cell types, neither the epidermal growth factor activity nor the Src family protein tyrosine kinases… CONTINUE READING

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