Mode of regulation of the ACh-sensitive K-channel by the muscarinic receptor in rabbit atrial cells

@article{Soejima1984ModeOR,
  title={Mode of regulation of the ACh-sensitive K-channel by the muscarinic receptor in rabbit atrial cells},
  author={Michimasa Soejima and Akinori Noma},
  journal={Pfl{\"u}gers Archiv},
  year={1984},
  volume={400},
  pages={424-431}
}
The mechanism underlying the regulation of the K-channel by the muscarinic receptor was examined with patch-clamp experiments in atrial cells isolated enzymatically from the rabbit heart. The patch-electrode and the recording chamber were perfused with various solutions while the activity of the K-channels in the membrane-patch was recorded continuously. 1) In the absence of muscarinic agonists, opening of K-channels occurred at a low frequency (basal activity). Application of ACh to the bath… CONTINUE READING