Mode of protective action of fosfomycin against dibekacin-induced nephrotoxicity in the dehydrated rats.

@article{Inouye1982ModeOP,
  title={Mode of protective action of fosfomycin against dibekacin-induced nephrotoxicity in the dehydrated rats.},
  author={Shigeharu Inouye and Tetsutaro Niizato and Izumi Komiya and Yasukatu Yuda and Yasushi Yamada},
  journal={Journal of pharmacobio-dynamics},
  year={1982},
  volume={5 12},
  pages={941-50}
}
We studied the mechanism on protective effect of fosfomycin against experimental nephrotoxicity induced by dibekacin. In order to simplify an experimental model, the dehydrated Wistar rats were used, because a single injection of dibekacin at 30 mg/kg induced acute renal failure in the dehydrated rats, characterized by alteration of urinalytic parameters… CONTINUE READING