Mode of potentiating action of cocaine in morphine analgesia.

@article{Shimada1988ModeOP,
  title={Mode of potentiating action of cocaine in morphine analgesia.},
  author={Akira Shimada and Takako Tsuda and Tomoji Yanagita},
  journal={Japanese journal of pharmacology},
  year={1988},
  volume={48 2},
  pages={
          185-93
        }
}
  • Akira Shimada, Takako Tsuda, Tomoji Yanagita
  • Published 1988
  • Chemistry, Medicine, Biology
  • Japanese journal of pharmacology
  • The mechanism of antinociceptive interactions among morphine, cocaine and alcohol was studied in mice, guinea pigs and rabbits. In the tail-pressure test in mice, cocaine and alcohol alone showed almost no antinociceptive effects at doses up to 8 mg/kg, s.c., and 4 g/kg, respectively. Alcohol at 2 g/kg, i.g., also did not influence the effect of morphine, while cocaine at 4 mg/kg, s.c., significantly potentiated the antinociceptive effects of not only morphine but also pentazocine. In an… CONTINUE READING

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