Mode of neuromuscular blocking action of a toxic phospholipase A2 from Pseudocerastes fieldi (Field's horned viper) snake venom.

@article{Tsai1983ModeON,
  title={Mode of neuromuscular blocking action of a toxic phospholipase A2 from Pseudocerastes fieldi (Field's horned viper) snake venom.},
  author={Ming Cheng Tsai and C. Y. Lee and Avner Bdolah},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={1983},
  volume={21 4},
  pages={
          527-34
        }
}
The effects of a toxic phospholipase A2 (Fr.Cb) isolated from the venom of Pseudocerastes fieldi were studied on the chick biventer cervicis muscle and the mouse phrenic nerve--diaphragm preparations. In the chick muscle, Fr.Cb (10 micrograms/ml) caused complete neuromuscular blockade without producing contracture or affecting the response of the muscle to acetylcholine. In the mouse diaphragm, Fr.Cb blocked the indirectly elicited contraction without affecting that evoked directly. In a low… CONTINUE READING