Mode of inhibition of rat liver tryptophan 2,3-dioxygenase by melatonin.

@article{Walsh1994ModeOI,
  title={Mode of inhibition of rat liver tryptophan 2,3-dioxygenase by melatonin.},
  author={Helen Ann Walsh and Santy Daya and Chris George Whiteley},
  journal={Journal of pineal research},
  year={1994},
  volume={16 4},
  pages={188-92}
}
Liver tryptophan 2,3-dioxygenase is a cytosolic enzyme that plays a crucial role in the regulation of circulating levels of tryptophan. Stimulation of the activity of this enzyme by heme enhances the catabolism of tryptophan, making less tryptophan available for uptake into the brain. Melatonin, the major hormone of the pineal gland, is shown to cause competitive inhibition of this enzyme (Ki = 2.70 microM). This structural analog of the substrate L-tryptophan is a negative homotropic… CONTINUE READING

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