Mode of cell migration to the superficial layers of fetal monkey neocortex

  title={Mode of cell migration to the superficial layers of fetal monkey neocortex},
  author={Pasko Raki{\'c}},
  journal={Journal of Comparative Neurology},
  • P. Rakić
  • Published 1 May 1972
  • Biology
  • Journal of Comparative Neurology
Golgi and electronmicroscopic methods were used to define the shapes and intercellular relationships of cells migrating from their sites of origin near the ventricular surface across the intermediate zone to the superficial neocortical layers of the parietooccipital region in the brains of 75‐ to 97‐day monkey fetuses. After mitotic division in either ventricular or subventricular zones, the cells enter the intermediate zone and assume an elongated bipolar form oriented toward the cortical… 
The mode of migration of neurons to the hippocampus: a Golgi and electron microscopic analysis in foetal rhesus monkey
It is indicated that during the middle and late stages of neuronal migration to the hippocampus radial glial fibres may guide postmitotic young neurons across the intermediate zone to the ammonic plate in the same way that they guide neurons migrating to the superficial and middle layers of the neocortical plate.
Postmitotic neurons migrate tangentially in the cortical ventricular zone.
The results reveal an extensive tangential dispersion of cortical cells mediated predominantly or exclusively by the non-radial migration of postmitotic neurons.
A golgi study of radial glial cells in developing monkey telencephalon: Morphogenesis and transformation into astrocytes
Radial glial cells impregnated by a modified del Rio Hortega rapid Golgi method were studied in the occipital lobes of 38 rhesus monkeys from embryonic day 48 to birth which occurs at E165 and in 27 postnatal animals to day 365.
Migration of immature neurons along tangentially oriented fibers in the subpial part of the fetal mouse medulla oblongata
It is strongly suggested that such tangential fibers, including leading processes of moving neurons, serve as guidance substrates for the relocation of immature neurons in the mouse subpial medullary region.
Neuronal migration during the early development of the cerebral cortex
This method provides a study of the three dimensional developmental features of the pseudostratified columnar epithelium up to the formation of the early cortex plate of mouse foetuses.
Chain Migration of Neuronal Precursors
Electron microscopic analysis of serial sections showed that during chain migration, neural precursors moved associated with each other and were not guided by radial glial or axonal fibers.
Ultrastructure of putative migrating cells in the cerebral cortex of Lacerta galloti
Cells considered to be migratory in the cerebral cortex of adult lizards are ultrastructurally of two types; cells with spongy chromatin show an increase in cytoplasmic organelles and progressive chromatin condensation as they travel from the ependymal layer to the granular layer.
Mode of neuronal migration of the pontine stream in fetal mice
From the arrangement of the immature neurons and their processes, it can be inferred that developing fibers act as guidance substrates for the translocation of embryonic pontine neurons.
Ontogeny and Structure of the Radial Goal Fiber System of the Developing Murine Cerebrum
Bipolar and monopolar radial astroglial forms are thought to serve an analogous role as guide to neuronal migration in the developing cerebellar cortex, essential for histogenesis of cortical structures of the central nervous system.


Cell migrations to the isocortex in the rat
Cells that took up tritiated thymidine (H‐3T) at various periods of intrauterine and early infant life in the periventricular proliferative zone and migrated to form the isocortex in the rat were
The migration of neuroblasts in the developing cerebral cortex.
In a study employing an autoradiographic technique in which tritiated thymidine was used, Angevine & Sidman (1961) concluded that the pattern of migration of the neuroblasts of the developing cerebral cortex was the reverse of that proposed by Tilney.
Embryonal and Postembryonal Development of Neurons of the Human Cerebral Cortex
The most characteristic feature of the cortical organisation, distinct from the nuclear and reticular subcortical formations, is that in its structure a multilayer and multi-level screen is present,
Observed changes in the population of microtubules and filaments within the cytoplasm of maturing axons and astrocytes have been studied during the early postnatal development of rat optic nerves suggest that the Filaments within axonsand astroCytes may be formed by the breakdown ofmicrotubules.
Autoradiographic Study of Cell Migration during Histogenesis of Cerebral Cortex in the Mouse
When the autoradiographic method is applied to tissues of animals killed serially, one can determine the time and place of origin of cells, their route and rate of migration, and their ultimate fate.
The Golgi-Cox Technique
The image of tangled and overlapping neural processes produced by the Golgi method is indeed more reminiscent of electronic wiring than are histological brain pictures provided by any other technique.
Embryonic vertebrate central nervous system: Revised terminology
A revision is proposed in which the four fundamental zones are termed the ventricular, subventricular, intermediate, and marginal zones, each defined according to the form, behavior, and fate of its constituent cells.
Modality and topographic properties of single neurons of cat's somatic sensory cortex.
Observations upon the modality and topographical attributes of single neurons of the first somatic sensory area of the cat’s cerebral cortex, the analogue of the cortex of the postcentral gyrus in the primate brain, support an hypothesis of the functional organization of this cortical area.