Mode of antinociceptive and toxic action of alkaloids of Aconitum spec.

  title={Mode of antinociceptive and toxic action of alkaloids of Aconitum spec.},
  author={Ulrike T. Gutser and Johannes Friese and J{\"u}rgen F. Heubach and Th. Matthiesen and Norma Selve and Bob Wilffert and Johannes Gleitz},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
Abstract Extracts of the plant Aconitum spec. are used in traditional Chinese medicine predominantly as anti-inflammatory and analgesic agents, the latter allegedly equally potent as morphine but without any habit-forming potential. As the only pharmacologically active compounds, the C19 diterpenoid alkaloid aconitine, and some of its derivatives, have been proven to be antinociceptive in different analgesic assays, but the mode of action is unknown. To elucidate the mode of action, ten… 
Anesthetic Agents of Plant Origin: A Review of Phytochemicals with Anesthetic Activity
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Naturally occurring antinociceptive substances from plants
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Ester Hydrolysis Differentially Reduces Aconitine-Induced Anti-hypersensitivity and Acute Neurotoxicity: Involvement of Spinal Microglial Dynorphin Expression and Implications for Aconitum Processing
The results suggest that both the C8-acetyl and C14-benzoyl groups are essential for aconitine to stimulate spinal microglial dynorphin A expression and subsequent anti-hypersensitivity, which can be separated from neurotoxicity, because both benzoylaconine and aconine differentially produced anti- Hypersensitivity and neurotoxicity.
Biological activity of plant extracts: novel analgesic drugs
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The toxicology and detoxification of Aconitum: traditional and modern views
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Pharmacological effects of two polar fractions from Annona coriacea Mart in animal models
It is demonstrated that fractions of A. coriacea have antinociceptive and anti-inflammatory effects, supporting the use of this plant in folk medicine.
Effect of Camellia oleifera essential oil on transdermal delivery of aconitine from carbopol gel
The data suggest that aconitine gel may be a safe local analgesic agent and camellia oleifera essential oil is a suitable penetration enhancer for acon itine gel.
A QSAR analysis to explain the analgesic properties of Aconitum alkaloids
A quantitative structure‐activity relationship (QSAR) analysis was performed to study the effect of chemical substitutes in the analgesic potency of alkaloids available in Chinese Aconitum roots to find the parameters explaining analgesic activity.


The extract of an Oriental medicine "bushi", Aconitum japonicum roots (raw), was fractionated monitored by the analgesic activity in the tail pressure test, leading to the isolation of a mixture of
[Analgesic action and absence of physical dependence of 3-acetylaconitine].
The results demonstrate that AAc belongs to the non-nacrotic analgesic, and suggested that analgesic action of AAc may be related to the monoamine level in brain.
Pharmacological actions of aconitine alkaloids.
These alkaloids more or less potentiated the hexobarbital anesthesia, inhibited the revolution of the wheel cage, and reduced the rectal temperature in mice, indicating that they have a depressant activity on the central nervous system.
Antiinflammatory principles of Aconitum roots.
The methanol extracts of Aconitum roots have shown inhibition of increased vascular permeability induced by acetic acid and of hind paw edema produced by carrageenin in mice, and the aconitines have reduced the granulation tissue formation of the chorio-allantoic membrane of the chick embryo.
The toxicity of aconitine and its analogs and their effects on cardiac contractile function
The results indicated so far that AC and its related compounds showed no beneficial but harmful effect on the cardial contractive function, Hence, in case should Fu-Zi (aconite) be applied for the treatment of cardiovascular diseases.
[Anti-inflammatory and analgesic activities of N-deacetyllappaconitine and lappaconitine].
The results suggest that the anti-inflammatory actions of DLA and LA do not depend on stimulation of the pituitary-adrenal axis.
Mechanism of inhibitory action of mesaconitine in acute inflammations.
Mesaconitine inhibited carrageenin-induced hind-paw edema in sham-operated mice as well as adrenalectomized mice, demonstrating that the mechanism of the antiinflammatory activity of MA involves the central nervous system.