Mode of antinociceptive and toxic action of alkaloids of Aconitum spec.

@article{Gutser1997ModeOA,
  title={Mode of antinociceptive and toxic action of alkaloids of Aconitum spec.},
  author={Ulrike T. Gutser and Johannes Friese and J{\"u}rgen F. Heubach and Th. Matthiesen and Norma Selve and Bob Wilffert and Johannes Gleitz},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1997},
  volume={357},
  pages={39-48}
}
Abstract Extracts of the plant Aconitum spec. are used in traditional Chinese medicine predominantly as anti-inflammatory and analgesic agents, the latter allegedly equally potent as morphine but without any habit-forming potential. As the only pharmacologically active compounds, the C19 diterpenoid alkaloid aconitine, and some of its derivatives, have been proven to be antinociceptive in different analgesic assays, but the mode of action is unknown. To elucidate the mode of action, ten… 
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References

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The extract of an Oriental medicine "bushi", Aconitum japonicum roots (raw), was fractionated monitored by the analgesic activity in the tail pressure test, leading to the isolation of a mixture of
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TLDR
The results demonstrate that AAc belongs to the non-nacrotic analgesic, and suggested that analgesic action of AAc may be related to the monoamine level in brain.
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TLDR
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TLDR
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TLDR
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TLDR
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