Mode of antinociceptive action of flupirtine in the rat.

  title={Mode of antinociceptive action of flupirtine in the rat.},
  author={Istvan Szelenyi and Bernhard Nickel and Harald O. Borbe and Kay Brune},
  journal={British journal of pharmacology},
  volume={97 3},
1. Flupirtine is a novel, centrally acting, non-opioid analgesic agent. The present investigation was undertaken to ascertain which neuronal systems might be responsible for its antinociceptive effect in rodents. The antinociceptive responses to the test compounds were examined in the tail-flick test. 2. The selective destruction of noradrenergic pathways by 6-hydroxydopamine considerably reduced the flupirtine-induced inhibition of nociceptive responses but not the clonidine-induced… CONTINUE READING


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