Mode of action of trabectedin in myxoid liposarcomas

  title={Mode of action of trabectedin in myxoid liposarcomas},
  author={Silvana Di Giandomenico and Roberta Frapolli and Ezia Bello and Sarah Uboldi and Simonetta Andrea Licandro and Sergio Marchini and Luca Beltrame and Silvia Brich and Valentina Mauro and Elena Tamborini and Silvana Pilotti and Paolo Giovanni Casali and Federica Del Grosso and Roberta Sanfilippo and Alessandro Gronchi and Roberto Mantovani and Raffaella Gatta and Carlos M Galmarini and Jos{\'e}-Maria Fernandez Sousa-Faro and Maurizio D'Incalci},
To elucidate the mechanisms behind the high sensitivity of myxoid/round cell liposarcoma (MRCL) to trabectedin and the suggested selectivity for specific subtypes, we have developed and characterized three MRCL xenografts, namely ML017, ML015 and ML004 differing for the break point of the fusion gene FUS-CHOP, respectively of type I, II and III. FUS-CHOP binding to the promoters of some target genes such as Pentraxin 3 or Fibronectin 1, assessed by chromatin immunoprecipitation, was strongly… CONTINUE READING
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