Mode of action of thyroid tumor formation in the male Long-Evans rat administered high doses of alachlor.

@article{Wilson1996ModeOA,
  title={Mode of action of thyroid tumor formation in the male Long-Evans rat administered high doses of alachlor.},
  author={A. G. Wilson and Daryl C Thake and W E Heydens and D W Brewster and Kathy J Hotz},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1996},
  volume={33 1},
  pages={16-23}
}
Chronic administration of alachlor in the diet at a level of 126 mg/kg/day has previously been shown to cause an increase in benign thyroid follicular cell tumors in male Long-Evans rats. Studies were conducted to elucidate the mechanism of the alachlor-induced thyroid tumors in the male rat by evaluating changes in parameters that are collectively associated with a hormonally mediated mode of action for thyroid neoplasia. Male Long-Evans rats were administered 126 mg alachlor/kg body wt/day… CONTINUE READING