Mode of action of the 2-phenylquinoline efflux inhibitor PQQ4R against Escherichia coli

@inproceedings{Machado2017ModeOA,
  title={Mode of action of the 2-phenylquinoline efflux inhibitor PQQ4R against Escherichia coli},
  author={Diana Machado and Laura Beatriz Vieira Fernandes and Sofia Santos Costa and Rolando Cannalire and Giuseppe Manfroni and Oriana Tabarrini and Isabel Sofia Lopes Couto and Stefania Sabatini and Miguel Viveiros},
  booktitle={PeerJ},
  year={2017}
}
Efflux pump inhibitors are of great interest since their use as adjuvants of bacterial chemotherapy can increase the intracellular concentrations of the antibiotics and assist in the battle against the rising of antibiotic-resistant bacteria. In this work, we have described the mode of action of the 2-phenylquinoline efflux inhibitor (4-(2-(piperazin-1-yl)ethoxy)-2-(4-propoxyphenyl) quinolone - PQQ4R), against Escherichia coli, by studding its efflux inhibitory ability, its synergistic activity… CONTINUE READING
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