Mode of action of tetrahydrolipstatin: a derivative of the naturally occurring lipase inhibitor lipstatin.

@article{Borgstrm1988ModeOA,
  title={Mode of action of tetrahydrolipstatin: a derivative of the naturally occurring lipase inhibitor lipstatin.},
  author={B. Borgstr{\"o}m},
  journal={Biochimica et biophysica acta},
  year={1988},
  volume={962 3},
  pages={
          308-16
        }
}
  • B. Borgström
  • Published 1988
  • Chemistry, Medicine
  • Biochimica et biophysica acta
Tetrahydrolipstatin is a specific lipase inhibitor derived from lipstatin, a lipid produced by Streptomyces toxytricini. In addition to pancreatic lipase, it is shown in the present study that tetrahydrolipstatin also inhibits human gastric lipase, carboxyl ester lipase (cholesterol esterase) of pancreatic origin and the closely related bile-salt-stimulated lipase of human milk. It does not inhibit the exocellular lipase from Rhizopus arrhizus or a lipase recently isolated from Staphylococcus… Expand
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245 Citations
Highly Influential Citations
5
Background Citations
51
Methods Citations
7
Results Citations
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245 Citations

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Citation Type

On the inhibition of microbial lipases by tetrahydrolipstatin.
  • 6
Effects of tetrahydrolipstatin, a lipase inhibitor, on absorption of fat from the intestine of the rat.
  • 60
Inhibition of human pancreatic lipase by tetrahydrolipstatin: Further kinetic studies showing its reversibility
  • 40
Interactions of lipoprotein lipase with the active-site inhibitor tetrahydrolipstatin (Orlistat).
  • 119
Mass spectrometric evidence of covalently-bound tetrahydrolipstatin at the catalytic serine of Streptomyces rimosus lipase.
  • 18
  • Highly Influenced
Identification of lipase inhibitor from orthosiphon stamineus benth and analysis of lipase-inhibitor complex interaction
  • PDF
A comparative kinetic study on human pancreatic and Thermomyces lanuginosa lipases: Inhibitory effects of tetrahydrolipstatin in the presence of lipid substrates
  • 7
Inhibition of lipases from Chromobacterium viscosum and Rhizopus oryzae by tetrahydrolipstatin.
  • 8
Identification of the active‐site serine in human pancreatic lipase by chemical modification with tetrahydrolipstatin
  • 71
  • PDF
Operon for Biosynthesis of Lipstatin, the Beta-Lactone Inhibitor of Human Pancreatic Lipase
  • 20
  • PDF
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References

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Lipstatin, an inhibitor of pancreatic lipase, produced by Streptomyces toxytricini. II. Chemistry and structure elucidation.
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Human gastric lipase. The effect of amphiphiles.
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  • Chemistry, Medicine
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