Mode of action of tetrahydrolipstatin: a derivative of the naturally occurring lipase inhibitor lipstatin.

@article{Borgstrm1988ModeOA,
  title={Mode of action of tetrahydrolipstatin: a derivative of the naturally occurring lipase inhibitor lipstatin.},
  author={B. Borgstr{\"o}m},
  journal={Biochimica et biophysica acta},
  year={1988},
  volume={962 3},
  pages={
          308-16
        }
}
  • B. Borgström
  • Published 1988
  • Chemistry, Medicine
  • Biochimica et biophysica acta
Tetrahydrolipstatin is a specific lipase inhibitor derived from lipstatin, a lipid produced by Streptomyces toxytricini. In addition to pancreatic lipase, it is shown in the present study that tetrahydrolipstatin also inhibits human gastric lipase, carboxyl ester lipase (cholesterol esterase) of pancreatic origin and the closely related bile-salt-stimulated lipase of human milk. It does not inhibit the exocellular lipase from Rhizopus arrhizus or a lipase recently isolated from Staphylococcus… Expand
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