Mode of action of quindoxin and substituted quinoxaline-di-N-oxides on Escherichia coli.

@article{Suter1978ModeOA,
  title={Mode of action of quindoxin and substituted quinoxaline-di-N-oxides on Escherichia coli.},
  author={W Newton Suter and A. Rosselet and F. Kn{\"u}sel},
  journal={Antimicrobial agents and chemotherapy},
  year={1978},
  volume={13 5},
  pages={770-83}
}
The effect of quindoxin on the synthesis of deoxyribonucleic acid (DNA), ribonucleic acid, and protein in Escherichia coli KL 399 was examined under aerobic and anaerobic conditions. In the absence of oxygen the synthesis of DNA was completely inhibited by 10 ppm of quindoxin, whereas the syntheses of ribonucleic acid and protein were not affected. Quinoxalin-di-N-oxides (QdNO) induce degradation of DNA in both proliferating and non-proliferating cells. polA, recA, recB, recC, exrA, and uvrA… CONTINUE READING