Mode of action of miconazole on yeasts: inhibition of the mitochondrial ATPase.

@article{Portillo1984ModeOA,
  title={Mode of action of miconazole on yeasts: inhibition of the mitochondrial ATPase.},
  author={Francisco Portillo and Carlos Gancedo},
  journal={European journal of biochemistry},
  year={1984},
  volume={143 2},
  pages={273-6}
}
Miconazole [( 1-[2-(2,4 dichlorophenyl)-2-(2,4 dichlorophenyl)methoxy]ethyl]-1 H-imidazole) completely inhibited growth of Saccharomyces cerevisiae and Candida albicans on glycerol at 10 microM . 50 microM was needed to achieve the same effect during growth on glucose. Miconazole inhibited competitively the mitochondrial ATPase of S. cerevisiae with a Ki of… CONTINUE READING