Mode of action of cannabinoids on nociceptive nerve endings

@article{Kress2009ModeOA,
  title={Mode of action of cannabinoids on nociceptive nerve endings},
  author={Michaela Kress and Rohini Kuner},
  journal={Experimental Brain Research},
  year={2009},
  volume={196},
  pages={79-88}
}
In recent years, cannabinoids have emerged as attractive alternatives or supplements to therapy for chronic pain states. However, in humans the activation of cannabinoid receptors in neurons of the central nervous system is associated with psychotropic side effects, temporary memory impairment and dependence, which arise via the effects of cannabinoids on forebrain circuits. For clinical exploitation of the analgesic properties of cannabinoids, a major challenge is to devise strategies that… CONTINUE READING

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