Mode of VAMP substrate recognition and inhibition of Clostridium botulinum neurotoxin F

@article{Agarwal2009ModeOV,
  title={Mode of VAMP substrate recognition and inhibition of Clostridium botulinum neurotoxin F},
  author={Rakhi Agarwal and J. W. Schmidt and Robert G. Stafford and Subramanyam Swaminathan},
  journal={Nature Structural &Molecular Biology},
  year={2009},
  volume={16},
  pages={789-794}
}
Clostridium botulinum neurotoxins (BoNTs) cleave neuronal proteins responsible for neurotransmitter release, causing the neuroparalytic disease botulism. BoNT serotypes B, D, F and G cleave and inactivate vesicle-associated membrane protein (VAMP), each at a unique peptide bond. The specificity of BoNTs depends on the mode of substrate recognition. We have investigated the mechanism of substrate recognition of BoNT F by determining the crystal structures of its complex with two substrate-based… CONTINUE READING

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