Mode of Action of Sulfanilyl Fluoroquinolones

@article{Alovero1998ModeOA,
  title={Mode of Action of Sulfanilyl Fluoroquinolones},
  author={F. Alovero and Marcelo J. Nieto and M. R. Mazzieri and R. Then and R. Manzo},
  journal={Antimicrobial Agents and Chemotherapy},
  year={1998},
  volume={42},
  pages={1495 - 1498}
}
ABSTRACT The mode of action of sulfanilyl fluoroquinolones (NSFQs) was investigated with NSFQ-104, NSFQ-105, and some structurally related compounds. Evidence arising from interactions withp-aminobenzoic acid and trimethoprim suggested that a sulfonamidelike mechanism of action makes little or no contribution to the in vitro activity of NSFQs. NSFQ-105 showed an activity that inhibits gyrase-catalyzed DNA supercoiling that is similar to the activity of other fluoroquinolones. Also, NSFQ-105… Expand
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