Mode of Action of Chloramphenicol

ACCORDING to Woolley1, chloramphenicol inhibits the utilization of phenylalanine in E. coli, due to its structural resemblance to that amino-acid. Truhaut, Lambin and Boyer2, on the other hand, have concluded from experiments with E. typhi that the antibiotic interferes in the early stages of the synthesis of tryptophane, which Fildes3 has formulated as… CONTINUE READING