Mode of Action: Inhibition of Androgen Receptor Function—Vinclozolin-Induced Malformations in Reproductive Development

@article{Kavlock2005ModeOA,
  title={Mode of Action: Inhibition of Androgen Receptor Function—Vinclozolin-Induced Malformations in Reproductive Development},
  author={R. Kavlock and A. Cummings},
  journal={Critical Reviews in Toxicology},
  year={2005},
  volume={35},
  pages={721 - 726}
}
  • R. Kavlock, A. Cummings
  • Published 2005
  • Biology, Medicine
  • Critical Reviews in Toxicology
  • Vinclozolin is a fungicide that has been shown to cause Leydig cell tumors and atrophy of the accessory sex glands in adult rodents. In addition, exposure of rats during pregnancy causes a pattern of malformations in the male urogenital tract. A wealth of standard toxicological studies and targeted research efforts is available related to this adverse effect, and these were used to evaluate the Human Relevance Framework (HRF) for noncancer health effects. Vinclozolin and two of its metabolites… CONTINUE READING
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