Mode and specificity of binding of the small molecule GANT61 to GLI determines inhibition of GLI-DNA binding

@inproceedings{Agyeman2014ModeAS,
  title={Mode and specificity of binding of the small molecule GANT61 to GLI determines inhibition of GLI-DNA binding},
  author={Akwasi Agyeman and Babal Kant Jha and Tapati Mazumdar and Janet A. Houghton},
  booktitle={Oncotarget},
  year={2014}
}
The GLI genes, GLI1 and GLI2, are transcription factors that regulate target genes at the distal end of the canonical Hedgehog (HH) signaling pathway (SHH->PTCH->SMO->GLI), tightly regulated in embryonic development, tissue patterning and differentiation. Both GLI1 and GLI2 are oncogenes, constitutively activated in many types of human cancers. In colon cancer cells oncogenic KRAS-GLI signaling circumvents the HH-SMO-GLI axis to channel through and activate GLI in the transcriptional regulation… CONTINUE READING
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