Modafinil-induced conditioned place preference via dopaminergic system in mice.

  title={Modafinil-induced conditioned place preference via dopaminergic system in mice.},
  author={Thi-Lien Nguyen and Yu-Hua Tian and In-Jee You and Seok-Yong Lee and Choon-gon Jang},
  volume={65 8},
Modafinil, a psychostimulant, is used in the treatment of narcolepsy, shift work sleep disorder, and excessive daytime sleepiness associated with obstructive sleep apnea. Preclinical and clinical studies suggest that modafinil may have reinforcing effects. However, a possible rewarding property of modafinil has not been fully investigated. In this study, we assessed the potential rewarding property of modafinil using the conditioned place preference (CPP) paradigm in mice. Using radiolabeled… CONTINUE READING


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