Modafinil for excessive sleepiness associated with shift-work sleep disorder.

  title={Modafinil for excessive sleepiness associated with shift-work sleep disorder.},
  author={Charles A. Czeisler and James K Walsh and Thomas Roth and Rod J. Hughes and Kenneth P. Wright and Lilliam Kingsbury and Sanjay Arora and Jonathan R. L. Schwartz and Gwendolyn E Niebler and David F. Dinges},
  journal={The New England journal of medicine},
  volume={353 5},
BACKGROUND Patients with shift-work sleep disorder chronically have excessive sleepiness during night work and insomnia when attempting to sleep during the day. We evaluated the use of modafinil for treating sleepiness in patients with this disorder. METHODS In a three-month, double-blind trial, we randomly assigned 209 patients with shift-work sleep disorder to receive either 200 mg of modafinil or placebo before the start of each shift. Assessments were performed with the use of the… CONTINUE READING