Modafinil for Atypical Depression: Effects of Open-label and Double-blind Discontinuation Treatment

@article{Vaishnavi2006ModafinilFA,
  title={Modafinil for Atypical Depression: Effects of Open-label and Double-blind Discontinuation Treatment},
  author={Sandeep Vaishnavi and Kishore M Gadde and Sayed Alamy and Wei Zhang and Kathryn M. Connor and Jonathan R. T. Davidson},
  journal={Journal of Clinical Psychopharmacology},
  year={2006},
  volume={26},
  pages={373-378}
}
Abstract: Atypical depression, with features of hypersomnia, hyperphagia, anergia, and rejection sensitivity, is a common presentation of major depressive disorder. There are few available effective therapies for this disorder. We test modafinil, a novel wake-promoting agent, as monotherapy for atypical depression in a double-blind, placebo-controlled, relapse prevention trial after open-label treatment. We found that modafinil significantly improved atypical depression symptoms during 12 weeks… 

Modafinil for attentional and psychomotor dysfunction in advanced cancer: a double-blind, randomised, cross-over trial

Modafinil in a single dose regimen was significantly superior to placebo regarding two cognitive tests of psychomotor speed and attention and subjective scores of depression and drowsiness were significantly improved by modafinIL.

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Clearly larger well designed placebo-controlled studies with longer follow-up accompanied by evaluations of tolerance/dependence are warranted before psychostimulants can be recommended in routine clinical practice for the treatment of MDD.

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The term atypical depression as a preferentially monoamine oxidase inhibitor (MAOI)-responsive state was first introduced by West and Dally in 1959, and in this "post- MAOI" era, no novel compound or group of drugs has been clearly shown to have good efficacy in atypicals depression, leaving the treatment of atypICAL depression as an unmet need.

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Findings suggest that modafinil may improve quality of life in patients with cancer, undergoing cancer treatment, and receiving opioid therapy by enhancing vigilance and cognitive performance.

Modafinil: Not Just for Sleep Disorders? Off-Label Use of This Stimulant Might Improve Mood Disorders, ADHD, and Other Conditions

How the drug promotes wakefulness, how it might improve cognitive function, and what the evidence reveals about off-label indications are discussed are discussed.

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In this pilot study modafinil was well-tolerated and effective for fatigue in patients with cancer, and improvements were also seen in mood, quality of life, and functional status.

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There is some evidence that in the short-term, PS reduce symptoms of depression, Whilst this reduction is statistically significant, the clinical significance is less clear.

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