Modafinil binds to the dopamine uptake carrier site with low affinity.

@article{Mignot1994ModafinilBT,
  title={Modafinil binds to the dopamine uptake carrier site with low affinity.},
  author={Emmanuel Mignot and Seiji Nishino and C Guilleminault and William C. Dement},
  journal={Sleep},
  year={1994},
  volume={17 5},
  pages={
          436-7
        }
}
Modafinil is a stimulant compound with an unknown mechanism of action that has been used successfully to control excessive daytime sleepiness in narcoleptic patients in Europe (1,2). The compound also has a minimal effect on cataplexy and other accessory symptoms of the narcolepsy tetrad (1,2). It is well tolerated and is generally preferred to amphetamine and related compounds in the countries where it is available. The mode of action of modafinil is still not understood. The compound has been… Expand
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On acutely isolated neurons, modafinil evoked D2-receptor-mediated outward currents in tyrosine-hydroxylase positive cells, identified by single-cell RT-PCR, which reversed polarity near the K(+) equilibrium potential and were unchanged in the presence of nomifensine. Expand
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Results show that modafinil has some cocaine-like discriminative stimulus effects and, like other abused stimulants, can serve as a reinforcer at high doses. Expand
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References

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Role of catecholamines in the modafinil and amphetamine induced wakefulness, a comparative pharmacological study in the cat
TLDR
The results suggest that the arousal effect of modafinil does not depend on the availability of the endogenous catecholamines but results from an enhancement of alpha 1- and beta-receptor activity and that the waking and behavioral effects of amphetamine may be mainly due to an increase in dopamine release. Expand
Central alpha 1-adrenergic stimulation in relation to the behaviour stimulating effect of modafinil; studies with experimental animals.
TLDR
Modafinil appears to produce a strong stimulating effect in rodents and in primates, and could be linked to modulation (stimulation) of central alpha 1-adrenoceptors unaccompanied by peripheral sympathetic effects, which is unexpected. Expand
Comparative effects of modafinil and amphetamine on daytime sleepiness and cataplexy of narcoleptic dogs.
TLDR
Results suggest that the pharmacological property of modafinil is distinct from amphetamine, and validates the use of this canine model for the screening of stimulant compounds. Expand
Effect of modafinil and amphetamine on the rat catecholaminergic neuron activity
TLDR
Modafinil was unable to modify the firing pattern of central dopaminergic and noradrenergic neurons in the rat, while amphetamine consistently inhibited their activity, and the waking effect of modafInil does not seem to be mediated by the catecholaminergic neuron activity per se. Expand
Cocaine receptors labeled by [3H]2 beta-carbomethoxy-3 beta-(4-fluorophenyl)tropane.
TLDR
The results show that [ 3H]CFT and [3H]cocaine bind to a similar spectrum of sites in monkey caudate putamen, with a high positive correlation (r, 0.99, p less than 0.001) between the affinities of drugs at sites labeled by [3h]C FT and [4-fluorophenyl)-tropane. Expand
Successful treatment of idiopathic hypersomnia and narcolepsy with modafinil
TLDR
Modafinil, a putative central alpha 1 adrenergic agonist, was tested in idiopathic hypersomnia and narcolepsy and produces, in most cases, no peripheric sides effects, does not disturb night sleep and is never responsible of tolerance of drug dependence. Expand
Cocaine receptors labeled by H-2beta-carbomethoxy-3-beta-(4fluorophenyl)topane. Molec Pharmaco/1989;36: 518-24
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Comparative effects of amphetamine and modafinil on cataplexy and daytime sleepiness in narcoleptic canines
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parative effects of amphetamine and modafinil on cataplexy and daytime sleepiness in narcoleptic canines
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Effects ofmodafinil on the symptomatology of human narcolepsy
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