Modafinil and cortical gamma-aminobutyric acid outflow. Modulation by 5-hydroxytryptamine neurotoxins.

@article{Tanganelli1995ModafinilAC,
  title={Modafinil and cortical gamma-aminobutyric acid outflow. Modulation by 5-hydroxytryptamine neurotoxins.},
  author={Sergio Tanganelli and Miguel P{\'e}rez de la Mora and Luca Ferraro and Jesus Mendez-Franco and Lorenzo Beani and Francis A. Rambert and Kjell Fuxe},
  journal={European journal of pharmacology},
  year={1995},
  volume={273 1-2},
  pages={63-71}
}
The acute or chronic administration of modafinil, (diphenyl-methyl-sulfinyl-2-acetamide, 30 mg/kg s.c.) decreased gamma-amino-butyric acid (GABA) outflow from the cerebral cortex of freely moving guinea pigs and rats. In 5,7-dihydroxytryptamine intracerebroventricularly pretreated guinea pigs, the effect of modafinil on GABA outflow was reversed and the noradrenaline cortical levels increased. Prazosin (35.8 ng/kg i.p.) blocked the drug-induced increase in GABA efflux. In vitro experiments… CONTINUE READING

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