Modafinil activates cortical and subcortical sites in the sleep-deprived state.

@article{Thomas2006ModafinilAC,
  title={Modafinil activates cortical and subcortical sites in the sleep-deprived state.},
  author={Robert Joseph Thomas and Kenneth Kwong},
  journal={Sleep},
  year={2006},
  volume={29 11},
  pages={1471-81}
}
UNLABELLED SUBJECT OBJECTIVES: To assess the effect of the wake-promoting drug modafinil on working memory and brain activation in the executive network, following a single night of sleep deprivation. DESIGN Randomized, placebo-controlled, 4-arm, double-blind evaluation of a single 200-mg dose of modafinil on working memory (1-, 2-, and 3-back)-related functional brain activation and performance following overnight sleep deprivation. SETTING General Clinical Research Center, Biomedical… CONTINUE READING

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