Modafinil: a double-blind multicentric study.

  title={Modafinil: a double-blind multicentric study.},
  author={Michel M. Billiard and Alain Besset and Jacques Y. Montplaisir and F. Laffont and Françoise Goldenberg and Jacques Weill and Serge Lubin},
  volume={17 8 Suppl},
Modafinil is a central putative alpha-1 postsynaptic agonist with vigilance-promoting properties. Fifty narcoleptics (33 male and 17 female) participated in a multicentric study aimed at assessing the effects of the compound on night sleep, feeling on awakening, excessive daytime sleepiness and cataplexy. Modafinil was administered in a double-blind cross-over design at a daily dosage of 300 mg versus placebo. The duration of the study was 12 weeks, including a 2-week "run in" period with… CONTINUE READING

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