ModE-dependent molybdate regulation of the molybdenum cofactor operon moa in Escherichia coli.

@article{Anderson2000ModEdependentMR,
  title={ModE-dependent molybdate regulation of the molybdenum cofactor operon moa in Escherichia coli.},
  author={Linda S Anderson and ELIZABETH MCNAIRN and Thomas Lubke and Richard N. Pau and David H. Boxer},
  journal={Journal of bacteriology},
  year={2000},
  volume={182 24},
  pages={
          7035-43
        }
}
The expression of the moa locus, which encodes enzymes required for molybdopterin biosynthesis, is enhanced under anaerobiosis but repressed when the bacterium is able to synthesize active molybdenum cofactor. In addition, moa expression exhibits a strong requirement for molybdate. The molybdate enhancement of moa transcription is fully dependent upon the molybdate-binding protein, ModE, which also mediates molybdate repression of the mod operon encoding the high-affinity molybdate uptake… CONTINUE READING

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