Moclobemide in social phobia: a controlled dose-response trial.

  title={Moclobemide in social phobia: a controlled dose-response trial.},
  author={Russell Noyes and Georges Moroz and Jonathan R. T. Davidson and Michael R. Liebowitz and Allan Davidson and Jeffrey L. Siegel and Jan Bell and John W. Cain and S m Curlik and Thomas A. Kent and R. Bruce Lydiard and Alan G. Mallinger and Mark H. Pollack and Mark Rapaport and Stephen A Rasmussen and Doris Hedges and Edward Schweizer and Eberhard H. Uhlenhuth},
  journal={Journal of clinical psychopharmacology},
  volume={17 4},
Although the monoamine oxidase inhibitor phenelzine has proven efficacious in social phobia, the risk of hypertensive crises has reduced its acceptability. The reversible monoamine oxidase inhibitor moclobemide has less potential for such reactions, but its efficacy in this disorder remains unproven. A double-blind, placebo-controlled study was undertaken to assess the efficacy and safety of fixed doses of moclobemide. After a 1-week placebo run-in, subjects with social phobia were randomly… CONTINUE READING
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