Moclobemide discontinuation syndrome predominantly presenting with influenza-like symptoms

@article{Curtin2002MoclobemideDS,
  title={Moclobemide discontinuation syndrome predominantly presenting with influenza-like symptoms},
  author={François Curtin and Patricia Berney and C. Kaufmann},
  journal={Journal of Psychopharmacology},
  year={2002},
  volume={16},
  pages={271 - 272}
}
A case of moclobemide discontinuation syndrome who predominantly presented with influenza-like symptoms is presented. Sertraline treatment did not modify the symptoms, which may suggest different mechanisms with regard to different antidepressant drug discontinuation syndromes. Implications for clinical care are reviewed. 
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References

SHOWING 1-10 OF 10 REFERENCES
Selective serotonin reuptake inhibitor discontinuation syndrome: proposed diagnostic criteria.
OBJECTIVE To establish specific criteria by which selective serotonin reuptake inhibitor (SSRI) discontinuation syndrome may be identified. DATA SOURCES MEDLINE and PSYCHLIT databases were searchedExpand
Serotonin reuptake inhibitor withdrawal.
TLDR
Reports of withdrawal symptoms in a retrospective chart review of 352 patients treated in an outpatient clinic with the nonselective serotonin reuptake inhibitor clomipramine or with one of the selective SSRIs, fluoxetine, fluvoxamine, paroxettine, or sertraline suggest a role has been suggested for serotonin in coordinating sensory and autonomic function with motor activity. Expand
Moclobemide for anxiety disorders: a focus on moclobemide for panic disorder
TLDR
The data suggest moclobemide is a well tolerated and effective treatment for panic disorder and Evaluation of the tolerability in a long-term study of up to 1 year is still in progress. Expand
Withdrawal Phenomena Associated with Antidepressant and Antipsychotic Agents
TLDR
The withdrawal of heterocyclic antidepressants and antipsychotic agents can produce nausea, emesis, anorexia, diarrhoea, rhinorrhoea, diaphoresis, myalgias, paraesthesias, anxiety, agitation, restlessness and insomnia and is usually prevented by gradually reducing the total daily dosage of the pertinent drug. Expand
Moclobemide safety: monitoring a newly developed product in the 1990s.
TLDR
The safety profile of the product after 3 years on world markets is presented, largely unchanged from those observed at 1 and 2 years postlaunch, when the estimated exposed populations were 168,000 and 328,000, respectively. Expand
Antidepressant Discontinuation Syndromes
TLDR
Discontinuation symptoms have received little systematic study and most of the recommendations made here are based on anecdotal data or expert opinion, so research is needed to provide a firm evidence base for future recommendations. Expand
Pre-clinical pharmacology of moclobemide. A review of published studies.
TLDR
Moclobemide only slightly potentiates the pressor effect of oral tyramine in freely moving rats, again in contrast to tranylcypromine; it is not anti-cholinergic and is free of hepatotoxicity. Expand
Biochemistry and pharmacology of reversible inhibitors of MAO-A agents: focus on moclobemide.
TLDR
Moclobemide administration leads to increased monoamine receptor stimulation, reversal of reserpine induced behavioral effects, selective depression of REM sleep, down regulation of beta-adrenoceptors and increases in plasma prolactin and growth hormone levels which suggest a neuroprotective role. Expand
Differential changes in brain and platelet 5-HT concentrations after steady-state achievement and repeated administration of antidepressant drugs in mice
TLDR
Compared in male NMRI mice the simultaneous evolution of blood serotonin (5-HT) concentrations, and 5-HT parameters in the dorsal raphe, caudate nucleus and frontal cortex after clomipramine, fluoxetine and moclobemide treatments is compared to show significantly different effects between central and peripheral indices of 5- HT metabolism according to time and to the antidepressant assessed. Expand
Antidepressant discontinuation syndromes. Clinical relevance, prevention and management
  • Drug Safety
  • 2001