Moclobemide: a paradigm of research in clinical psychopharmacology

  title={Moclobemide: a paradigm of research in clinical psychopharmacology},
  author={Jules Angst and R. Amrein and Max Stabl},
  journal={International Clinical Psychopharmacology},
The pre-clinical development of moclobemide is an example of broad research combined with serendipity. Moclobemide was first hypothesized as being an antilipaemic or antibiotic, but the screenings were negative. The search for its antidepressant qualities, based on anticholinergic tests, also proved negative and moclobemide was then suspected of being an antipsychotic before its specific and reversible monoamine oxidase (MAO)-A inhibition qualities were detected. After the establishment of its… Expand
5 Citations
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