Mobilization with granulocyte colony-stimulating factor blocks medullar erythropoiesis by depleting F4/80(+)VCAM1(+)CD169(+)ER-HR3(+)Ly6G(+) erythroid island macrophages in the mouse.

@article{Jacobsen2014MobilizationWG,
  title={Mobilization with granulocyte colony-stimulating factor blocks medullar erythropoiesis by depleting F4/80(+)VCAM1(+)CD169(+)ER-HR3(+)Ly6G(+) erythroid island macrophages in the mouse.},
  author={Rebecca N Jacobsen and Catherine E. Forristal and Liza Jane Raggatt and Bianca Nowlan and Val{\'e}rie Barbier and Simranpreet Kaur and Nico Van Rooijen and Ingrid G Winkler and Allison R Pettit and J L{\'e}vesque},
  journal={Experimental hematology},
  year={2014},
  volume={42 7},
  pages={547-61.e4}
}
Similarly to other tissues, the bone marrow contains subsets of resident tissue macrophages, which are essential to maintain bone formation, functional hematopoietic stem cell (HSC) niches, and erythropoiesis. Pharmacologic doses of granulocyte colony-stimulating factor (G-CSF) mobilize HSC in part by interfering with the HSC niche-supportive function of BM resident macrophages. Because bone marrow macrophages are key to both maintenance of HSC within their niche and erythropoiesis, we… CONTINUE READING