Mobilization of tumor cells and hematopoietic progenitor cells into peripheral blood of patients with solid tumors.

@article{Brugger1994MobilizationOT,
  title={Mobilization of tumor cells and hematopoietic progenitor cells into peripheral blood of patients with solid tumors.},
  author={W. E. Brugger and Klaus J. Bross and Markus Glatt and Frank S Weber and Roland H. Mertelsmann and Lothar Kanz},
  journal={Blood},
  year={1994},
  volume={83 3},
  pages={636-40}
}
Peripheral blood progenitor cells (PBPCs) are increasingly used for autografting after high-dose chemotherapy. One advantage of PBPCs over the use of autologous bone marrow would be a reduced risk of tumor-cell contamination. However, the actual level of tumor cells contaminating PBPC harvests is poorly investigated. It is currently not known whether mobilization of PBPCs might also result in mobilization of tumor cells. We evaluated 358 peripheral blood samples from 46 patients with stage IV… CONTINUE READING