Mobilization of hematopoietic stem cells in a thalassemic mouse model: implications for human gene therapy of thalassemia.

@article{Yannaki2010MobilizationOH,
  title={Mobilization of hematopoietic stem cells in a thalassemic mouse model: implications for human gene therapy of thalassemia.},
  author={Evangelia Yannaki and Nikoleta Psatha and Evangelia Athanasiou and Garyfalia Karponi and Varnavas C Constantinou and Anastasia Papadopoulou and Athanasia Tasouli and Panayotis Kaloyannidis and Ioannis Batsis and Minas Arsenakis and Achilles Anagnostopoulos and Athanasios Fassas},
  journal={Human gene therapy},
  year={2010},
  volume={21 3},
  pages={299-310}
}
Granulocyte colony-stimulating factor (G-CSF)-mobilized blood stem cells may become the preferable source of hematopoietic stem cells (HSCs) for gene therapy because of the higher yield of cells compared with conventional bone marrow harvesting. A G-CSF-associated risk of splenic rupture has been recognized in normal donors of HSCs, but limited information is available about the G-CSF effect in the presence of splenomegaly and extramedullary hematopoiesis. We investigated the G-CSF effect in a… CONTINUE READING
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A mouse model for

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