Mobilization of hematopoietic stem cells during homeostasis and after cytokine exposure.

@article{Abkowitz2003MobilizationOH,
  title={Mobilization of hematopoietic stem cells during homeostasis and after cytokine exposure.},
  author={Janis L. Abkowitz and Abigail E Robinson and Sujata Kale and Michael William Long and Jing Chen},
  journal={Blood},
  year={2003},
  volume={102 4},
  pages={1249-53}
}
We created parabiotic mice, joining ROSA26 and PeP3b animals, to study the trafficking of hematopoietic stem cells (HSCs) from marrow to blood and their return to marrow. The transfer of HSCs was assayed by secondary marrow transplantation and was 1.0% to 2.5% after 3, 6, 8, and 12 weeks. Thus, HSC homeostasis is primarily maintained by the retention of stem cells derived from replication events within the marrow, not the homing and engraftment of HSCs from the circulation. Of interest, the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 101 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 33 references

Similar Papers

Loading similar papers…