Mobilization of allogeneic peripheral blood stem cell donors with intravenous plerixafor mobilizes a unique graft.

@article{Schroeder2017MobilizationOA,
  title={Mobilization of allogeneic peripheral blood stem cell donors with intravenous plerixafor mobilizes a unique graft.},
  author={Mark A Schroeder and Michael Rettig and Sandra Mar{\'i}a del Carmen Garc{\'i}a L{\'o}pez and Stephanie Christ and Mark A. Fiala and William C. Eades and Fazia A Mir and Jin Shao and Kyle McFarland and Kathryn Trinkaus and William D. Shannon and Elena Deych and Jinsheng Yu and Ravi Vij and K Stockerl-Goldstein and Amanda Cashen and G L Uy and Camille N. Abboud and Peter Westervelt and John F. DiPersio},
  journal={Blood},
  year={2017},
  volume={129 19},
  pages={
          2680-2692
        }
}
A single subcutaneous (SC) injection of plerixafor results in rapid mobilization of hematopoietic progenitors, but fails to mobilize 33% of normal allogeneic sibling donors in 1 apheresis. We hypothesized that changing the route of administration of plerixafor from SC to IV may overcome the low stem cell yields and allow collection in 1 day. A phase 1 trial followed by a phase 2 efficacy trial was conducted in allogeneic sibling donors. The optimal dose of IV plerixafor was determined to be 0… CONTINUE READING
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