Mobilization and fusion of a non-recycling pool of synaptic vesicles under conditions of endocytic blockade.

@article{Poskanzer2004MobilizationAF,
  title={Mobilization and fusion of a non-recycling pool of synaptic vesicles under conditions of endocytic blockade.},
  author={Kira Poskanzer and Graeme W Davis},
  journal={Neuropharmacology},
  year={2004},
  volume={47 5},
  pages={714-23}
}
At vertebrate central synapses, it has been demonstrated that a resting pool of synaptic vesicles (SVs) exists that normally does not participate in SV release and recycling. It remains unclear whether SVs within the resting pool are capable of mobilization and fusion. Here, we combine live imaging of SV exo- and endocytosis using pH-sensitive GFP (synapto-pHluorins) with pharmacological and genetic manipulations of the SV cycle at the Drosophila NMJ. We demonstrate that a resting pool of SVs… CONTINUE READING

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