Mobility and subcellular localization of endogenous, gene-edited Tau differs from that of over-expressed human wild-type and P301L mutant Tau

Abstract

Alzheimer's disease (AD) and a subset of frontotemporal dementia termed FTLD-Tau are characterized by a massive, yet incompletely characterized and understood redistribution of Tau. To establish a framework for understanding this pathology, we used the genome-editing tool TALEN and generated Tau-mEOS2 knock-in mice to determine the mobility and subcellular… (More)
DOI: 10.1038/srep29074

Topics

6 Figures and Tables

Cite this paper

@inproceedings{Xia2016MobilityAS, title={Mobility and subcellular localization of endogenous, gene-edited Tau differs from that of over-expressed human wild-type and P301L mutant Tau}, author={Di Xia and Julia M. Gutmann and J{\"{u}rgen G{\"{o}tz}, booktitle={Scientific reports}, year={2016} }