Mobility and molecular orientation of vitamin E in liposomal membranes as determined by 19F NMR and fluorescence polarization techniques.

@article{Urano1993MobilityAM,
  title={Mobility and molecular orientation of vitamin E in liposomal membranes as determined by 19F NMR and fluorescence polarization techniques.},
  author={Shiro Urano and Michinori Matsuo and T Sakanaka and Ippei Uemura and Mao Koyama and Itsumaro Kumadaki and Kenji Fukuzawa},
  journal={Archives of biochemistry and biophysics},
  year={1993},
  volume={303 1},
  pages={10-4}
}
To elucidate the molecular orientation and mobility of alpha-tocopherol (vitamin E) in membranes, 19F nuclear magnetic resonance (NMR) was applied. In bilayer phosphatidylcholine (PC) liposomes, 19F NMR spin-spin relaxation times (T2) of 19F-labeled methyl groups on either the chromanol moiety or the isoprenoid side chain of alpha-tocopherol were significantly decreased compared to those for alpha-tocopherol in solution (CDCl3), suggesting that the vitamin E molecule exists in the lipid core of… CONTINUE READING

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