• Corpus ID: 91008639

Mobilisation de l'acide arachidonique et sensibilité au peptide ß-amyloïde

@inproceedings{Thomas2015MobilisationDL,
  title={Mobilisation de l'acide arachidonique et sensibilit{\'e} au peptide {\ss}-amylo{\"i}de},
  author={M{\'e}lanie Thomas},
  year={2015}
}
La maladie d’Alzheimer (MA) est un probleme majeur de sante publique. Elle se traduit par des atteintes de la memoire reposant sur des dysfonctionnements synaptiques induits par les oligomeres de peptide s-amyloide (As). Ceux-ci activent la phospholipase A2 cytosolique (cPLA2) qui libere l’acide arachidonique (ARA) des phospholipides (PL) membranaires neuronaux. L’acyl-CoA synthetase 4 (ACSL4) peut limiter cette liberation en favorisant la reincorporation d’ARA dans les PL. Dans l’alimentation… 

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