Mobile gene cassettes and integrons: moving antibiotic resistance genes in gram-negative bacteria.

@article{Hall1997MobileGC,
  title={Mobile gene cassettes and integrons: moving antibiotic resistance genes in gram-negative bacteria.},
  author={Ruth M Hall},
  journal={Ciba Foundation symposium},
  year={1997},
  volume={207},
  pages={192-202; discussion 202-5}
}
In Gram-negative pathogens, multiple antibiotic resistance is common and many of the known resistance genes are contained in mobile gene cassettes. Cassettes can be integrated into or deleted from their receptor elements, the integrons, or infrequently may be integrated at other locations via site-specific recombination catalysed by an integron-encoded recombinase. As a consequence, arrays of several different antibiotic resistance genes can be created. Over 40 gene cassettes and three distinct… CONTINUE READING
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